Women Scientists Winning Nobel 2009

This year's Nobel Prize has been announced. In Medicine, 2 women scientists + a man scientists from America share the prize "for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase". (About Nobel Prize)

It's the first time two women have shared in a single Nobel science prize. Over the years, a total of 10 women have won the prize in medicine. Blackburn, 60, who holds U.S. and Australian citizenship, is a professor of biology and physiology at the University of California, San Francisco. Greider, 48, is a professor in the department of molecular biology and genetics at John Hopkins University School of Medicine in Baltimore.London-born Szostak, 56, is a professor of genetics at Harvard Medical School and a researcher with the Howard Hughes Medical Institute.

Blackburn and Greider

The following article about their work is taken from Chicago Tribune
Excerpts from the citation awarding the 2009 Nobel Prize in physiology or medicine to awarded to Americans Elizabeth Blackburn, Carol Greider and Jack Szostak. The Karolinska Institute says the trio was honored for research that has implications for cancer and aging research.

This year's Nobel Prize in Physiology or Medicine is awarded to three scientists who have solved a major problem in biology: how the chromosomes can be copied in a complete way during cell divisions and how they are protected against degradation. The Nobel Laureates have shown that the solution is to be found in the ends of the chromosomes the telomeres — and in an enzyme that forms them — telomerase.The long, threadlike DNA molecules that carry our genes are packed into chromosomes, the telomeres being the caps on their ends. Elizabeth Blackburn and Jack Szostak discovered that a unique DNA sequence in the telomeres protects the chromosomes from degradation. Carol Greider and Blackburn identified telomerase, the enzyme that makes telomere DNA. These discoveries explained how the ends of the chromosomes are protected by the telomeres and that they are built by telomerase.

If the telomeres are shortened, cells age. Conversely, if telomerase activity is high, telomere length is maintained, and cellular senescence is delayed. This is the case in cancer cells, which can be considered to have eternal life. Certain inherited diseases, in contrast, are characterized by a defective telomerase, resulting in damaged cells. The award of the Nobel Prize recognizes the discovery of a fundamental mechanism in the cell, a discovery that has stimulated the development of new therapeutic strategies.

In conclusion, the discoveries by Blackburn, Greider and Szostak have added a new dimension to our understanding of the cell, shed light on disease mechanisms, and stimulated the development of potential new therapies.